• If you are citizen of an European Union member nation, you may not use this service unless you are at least 16 years old.

  • You already know Dokkio is an AI-powered assistant to organize & manage your digital files & messages. Very soon, Dokkio will support Outlook as well as One Drive. Check it out today!



Page history last edited by Mike McMahon 13 years, 2 months ago



RECOMMENDATIONS from NICE CG059 Osteoarthritis



If a person with osteoarthritis needs to take low dose aspirin, healthcare professionals should

consider other analgesics before substituting or adding an NSAID or COX-2 inhibitor (with a

PPI) if pain relief is ineffective or insufficient.


All oral NSAIDs/COX-2 inhibitors have analgesic effects of a similar magnitude but vary in

their potential GI, liver and cardio-renal toxicity and therefore when choosing the agent and

dose, healthcare professionals should take into account individual patient risk factors,

including age. When prescribing these drugs, consideration should be given to appropriate

assessment and/or ongoing monitoring of these risk factors.


When offering treatment with an oral NSAID/COX-2 inhibitor, the first choice should be

either a standard NSAID or a COX-2 inhibitor (other than etoricoxib 60 mg). In either case,

these should be coprescribed with a proton pump inhibitor (PPI), choosing the one with the

lowest acquisition cost.


Oral NSAIDs/COX-2 inhibitors should be used at the lowest effective dose for the shortest

possible period of time.




Where paracetamol or topical NSAIDs provide insufficient pain relief for people with

osteoarthritis, then the addition of an oral NSAID/COX-2 inhibitor to paracetamol should be





Comments (0)

You don't have permission to comment on this page.